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排序方式: 共有201条查询结果,搜索用时 15 毫秒
191.
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M A Martynova E M Manevich E L Vodovozova G I Muzia V V Bezuglov 《Biokhimii?a (Moscow, Russia)》1988,53(5):721-727
Interaction of prostaglandins (PG) with human plasma low density lipoproteins (LDL) was studied, using fluorescent spectroscopy and photoreactive labeling. It was demonstrated that PGE1 at low concentrations (less than 10(-9) M) induces specific lipid rearrangements on the surface of LDL globules. It was assumed that these rearrangements are brought about by the interaction of PG with apolipoprotein B to form short-living complexes. A possible mechanism and biological significance of the observed phenomenon are discussed. 相似文献
193.
F. M. Eroshkin A. V. Bayramov N. Y. Martynova A. G. Zaraisky 《Russian Journal of Bioorganic Chemistry》2012,38(3):338-340
Noggin (Noggin1) protein inhibits Smad1-dependent TGF-?? (BMP) signaling cascades by extracellular binding of BMP proteins. Recently, we identified two previously unknown members of the Noggin family, Noggin2 and Noggin4 proteins. In this work, using luciferase reporter constructs, it was shown that Noggin2 is able to inhibit in addition to the BMP-signaling cascade, the Activin/Nodal and Wnt signaling pathways in Xenopus laevis early embryos. The inhibition efficiency of Noggin2 is comparable to well-known extracellular inhibitors Cerberus and Follistatin. In addition to revealing novel properties of Noggin2, this work demonstrates that luciferase reporter constructs are a convenient tool for studying the regulation of molecular signaling cascades in the model of Xenopus laevis embryos. 相似文献
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5-Aminolevulinic acid (ALA), a precursor of porphyrin synthesis, increased the production of various porphyrin compounds in Candida guilliermondii cells. Metalloporphyrins and protoporphyrin IX (PPIX) were predominantly accumulated, respectively, at ALA concentrations of 0.2-0.4 mM and at those higher than 1.5 mM. 2,2;-Dipyridyl which complexed with bivalent metals significantly increased the content of endogenous PPIX even at ALA concentrations lower than 0.5 mM. Under these conditions, the yeast sensitivity to photodynamic effect of visible light (400-600 nm) dramatically increased due to photosensitization by endogenous PPIX. 相似文献
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Maria B. Tereshina Anastasiya S. Ivanova Fedor M. Eroshkin Daria D. Korotkova Alexey M. Nesterenko Andrey V. Bayramov Elena A. Solovieva Elena A. Parshina Eugeny E. Orlov Natalia Y. Martynova Andrey G. Zaraisky 《Genesis (New York, N.Y. : 2000)》2019,57(5)
The Agr family genes, Ag1, Agr2, and Agr3, encode for the thioredoxin domain containing secreted proteins and are specific only for vertebrates. These proteins are attracting increasing attention due to their involvement in many physiological and pathological processes, including exocrine secretion, cancer, regeneration of the body appendages, and the early brain development. At the same time, the mode by which Agrs regulate intracellular processes are poorly understood. Despite that the receptor to Agr2, the membrane anchored protein Prod1, has been firstly discovered in Urodeles, and it has been shown to interact with Agr2 in the regenerating limb, no functional homologs of Prod1 were identified in other vertebrates. This raises the question of the mechanisms by which Agrs can regulate regeneration in other lower vertebrates. Recently, we have identified that Tfp4 (three‐fingers Protein 4), the structural and functional homolog of Prod1 in Anurans, interacts with Agr2 in Xenopus laevis embryos. In the present work we show by several methods that the activity of Tfp4 is essential for the tadpole tail regeneration as well as for the early eye and forebrain development during embryogenesis. These data show for the first time the common molecular mechanism of regeneration regulation in amphibians by interaction of Prod1 and Agr2 proteins. 相似文献
198.
O S Gladysheva D M Kukushkina G I Martynova M Iu Ul'ianov 《Ukrainski? biokhimicheski? zhurnal》1979,51(6):587-591
A quantitative and qualitative biochemical investigation was carried out for the composition of water-soluble proteins in preparation of the bull's olfactory mucosa scrape. Comparing the results with those obtained for a similar preparation of a nonsensory nature (a preparation of a respiratory epithelium scrape) the authors found that the most electrically-mobile protein fractions differ in their physical properties and number. A reaction for glycoproteins showed that with an alcian blue an appropriate colour for acidic glycoproteins is given only by two protein fractions. The most electrically-mobile fraction with its visual colour of an olfactory pigment is probably identical to its water-soluble component absorbed on phosphatides. The second, weakly mobile protein is the main acidic glycoprotein of the olfactory mucus and besides it has a reaction for on alkaline phosphatase. 相似文献
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